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Zomacton is indicated for the long-term treatment of children who have growth failure due to inadequate secretion of growth hormone and for the long-term treatment of growth retardation due to Turner’s Syndrome confirmed by chromosome analysis.

Indications for: ZOMACTON

Growth failure in children due to inadequate endogenous GH secretion. Children with short stature associated with Turner syndrome. Children with idiopathic short stature (ISS). Children with short stature homeobox-containing gene (SHOX) deficiency. Children with short stature born small for gestational age (SGA) with no catch-up growth by age 2–4yrs. Replacement of endogenous GH in adults with GH deficiency. RELATED PRODUCTS

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Adult Dosage:

Give by SC inj to the back of upper arm, abdomen, buttock, or thigh. Rotate inj sites. Non-weight based: initially ~0.2mg/day (range: 0.15–0.3mg/day); increase dose in increments of ~0.1–0.2mg/day every 1–2mos based on response and serum IGF-1 levels. Weight-based: initially 0.006mg/kg/day; increase dose based on individual requirements to max 0.0125mg/kg/day. Obese: weight-based dosing not recommended. MORE ON HGH

Children Dosage:

Give by SC inj to the back of upper arm, abdomen, buttock, or thigh. Rotate inj sites. Individualize. Divide weekly dosage into equal doses over 3, 6 or 7 days. GH deficient: 0.18–0.3mg/kg/week (0.026–0.043mg/kg/day). Turner syndrome: up to 0.375mg/kg/week (up to 0.054mg/kg/day). ISS: up to 0.37mg/kg/week (up to 0.053 mg/kg/day). SHOX deficiency: 0.35mg/kg/week (0.05mg/kg/day). SGA: up to 0.47mg/kg/week (up to 0.067mg/kg/day). Discontinue once epiphyseal fusion has occurred.

ZOMACTON Contraindications:

Acute critical illness due to open heart surgery, abdominal surgery, multiple accidental trauma or those with acute respiratory failure. Children with closed epiphysis. Active malignancy. Diabetic retinopathy. History of upper airway obstruction or sleep apnea, severe obesity, or severe respiratory impairment in Prader-Willi syndrome (PWS) patients.

ZOMACTON Warnings/Precautions:

Increased mortality in those with acute critical illness (see Contraindications); weigh potential treatment benefit vs the potential risk. PWS: evaluate baseline respiratory function; monitor weight and for respiratory infection; interrupt if signs of upper airway obstruction and/or sleep apnea occurs. History of GHD secondary to intracranial neoplasm: monitor routinely for tumor progression or recurrence. Increased risk of developing malignancies. Monitor for increased growth or malignant changes of preexisting nevi. Diabetes. Obesity. Hypothyroidism. Scoliosis. Turner syndrome. Monitor thyroid function, glucose tolerance, and for intracranial hypertension (do baseline and periodic funduscopic exams). Hypoadrenalism: monitor for reduced serum cortisol levels. Elderly (consider lower starting dose). Neonates: reconstitute with normal saline for inj instead. Pregnancy, nursing mothers: reconstitute with normal saline or use benzyl alcohol-free formulation.