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Pristiq is a brand-name prescription drug that’s used to treat major depressive disorder (MDD) in adults. MDD is a serious mental health condition. It’s often called clinical depression, or simply depression.

Pristiq belongs to a class of antidepressants called serotonin-norepinephrine reuptake inhibitors (SNRIs). A class of drugs is a group of medications that work in a similar way. SNRIs increase the level of two chemicals (serotonin and norepinephrine) in your brain.

About Pristiq and How it Works

Pristiq or the generic Desvenlafaxine Succinate is an antidepressant that belongs to a class of drugs called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). Desvenlafaxine affects chemicals in the brain that are unbalanced in people with depression. SNRIs are typically used to treat depression. They may be an effective form of treatment for people who have had unsuccessful treatment with selective serotonin reuptake inhibitors, which only work on one chemical messenger. The generic alternative is not manufactured by the company that makes the brand product.

Depression is associated with low levels of serotonin and norepinephrine. These are neurotransmitters (chemical messengers) known to affect mood. Serotonin is sometimes called a “feel-good” chemical because it’s associated with positive feelings of wellbeing, while Norepinephrine is related to alertness and energy. RELATED PRODUCTS

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Conditions Treated by Pristiq

Brand name or generic Pristiq medication is used to treat major depressive disorder (MDD) in adults. Major Depressive Disorder, also known as clinical depression, is a medical condition that can affect many areas of your life. It impacts mood and behavior as well as various physical functions, such as appetite and sleep. People with MDD often lose interest in activities they once enjoyed and have trouble performing everyday activities.

Pristiq may also be prescribed to treat anxiety and panic attacks. Anxiety is a body’s natural response to stress. You may experience feelings of fear and apprehension of what is to come when preparing for a job interview, speaking in front of people or approaching a new experience. However, if your feelings of anxiety are extreme, last for longer than six months, and are interfering with your life, you may have an anxiety disorder. MORE ON ANXIETY MEDS

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Dosage Recommendations for Patients with Renal Impairment
The maximum recommended dose in patients with moderate renal impairment (24-hr creatinine clearance [ClCr] = 30 to 50 mL/min, Cockcroft-Gault [C-G]) is 50 mg per day. The maximum recommended dose in patients with severe renal impairment (ClCr 15 to 29 mL/min, C-G) or end-stage renal disease (ESRD, ClCr < 15 mL/min, C-G) is 25 mg every day or 50 mg every other day. Supplemental doses should not be given to patients after dialysis [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)].

Dosage Recommendations for Patients with Hepatic Impairment
The recommended dose in patients with moderate to severe hepatic impairment (Child-Pugh score 7 to 15) is 50 mg per day. Dose escalation above 100 mg per day is not recommended