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Adult Dosage:

Closed epiphyses: not recommended.

Children Dosage:

Administer before or after (+/–20 minutes) a meal/snack; rotate inj sites (upper arm, thigh, buttock or abdomen). <2yrs: not established. Individualized. ≥2yrs: initially 0.04 to 0.08mg/kg SC twice daily; may increase after 1 week by 0.04mg/kg per dose; max 0.12mg/kg twice daily.

INCRELEX Contraindications:

Growth promotion in patients with closed epiphyses. Malignant neoplasia or history of malignancy. IV administration.

INCRELEX Warnings/Precautions:

Not for secondary forms of IGF-1 deficiency. Correct thyroid and nutritional deficiencies before treatment. Measure preprandial glucose level before treatment and monitor until a tolerated dose is established. Reduce dose if hypoglycemia occurs despite adequate food intake with therapy. Monitor for lymphoid tissue hypertrophy complications. Monitor for malignant neoplasms; discontinue if develops. Do funduscopic exam for intracranial hypertension at the start of therapy, then periodically. Evaluate any child with onset of limp or hip/knee pain for possible slipped capital femoral epiphysis. Monitor for progression of scoliosis. Infants: avoid. Pregnancy. Nursing mothers. RELATED PRODUCTS

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Increlex is a man-made form of insulin-like growth factor-1 (IGF-1), a substance that is normally produced in the body. IGF-1 is important for the growth of bones and muscles. Increlex is used to treat growth failure in children whose bodies do not make enough IGF-1. Increlex is not for use in children who have growth hormone deficiency, malnutrition, underactive thyroid, or those who are taking long-term steroid medications.

Increlex should not be given to a child who has cancer, or a child who has finished growing (the bone growth plates are closed).

Increlex is not for use in children who have growth hormone deficiency, malnutrition, underactive thyroid, or those who are taking long-term steroid medications.

Before your child receives this medicine, tell the doctor if your child has diabetes, kidney disease, liver disease, a curved spine (scoliosis), or if the child has ever had an allergic reaction to a preservative called benzyl alcohol.

Increlex s injected under the skin. You and your child may be shown how to use injections at home. Make sure you fully understand how to give the injection and properly dispose of used needles and syringes.

Take care not to let your child’s blood sugar get too low while using this medicine. Know the signs of low blood sugar (hypoglycemia) and how to recognize them