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What is Fetzima?
Fetzima is a brand-name prescription drug. It’s used to treat major depressive disorder (MDD) in adults. This condition is also called depression.
Fetzima contains the drug levomilnacipran, which belongs to a class of drugs called serotonin-norepinephrine reuptake inhibitors (SNRIs). These drugs work by increasing levels of serotonin and norepinephrine (certain brain chemicals) in your body. This helps improve symptoms of MDD.
Fetzima comes as extended-release capsules that are taken by mouth once daily. It’s available in the following strengths: 20 milligrams (mg), 40 mg, 80 mg, and 120 mg.
In three different clinical studies, people’s depression symptoms were improved more with Fetzima treatment than with a placebo (treatment with no active drug).
In the studies, people’s depression symptoms were scored using a test called Montgomery-Asberg Depression Rating Scale (MADRS).
This test evaluates people’s moods (such as sadness), feelings of discomfort, quality of sleep, appetite level, ability to concentrate, and motivation to do certain activities. The test also looks at whether or not people are having thoughts of suicide. A lower MADRS score indicates fewer depression symptoms than a higher score does. RELATED PRODUCTS
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Dosage Forms & Strengths
Contains two 20mg capsules and twenty-six 40mg capsules
Major Depressive Disorders
SNRI indicated for major depressive disorders in adults
20 mg PO qDay x2 days initially; THEN
Increase to 40 mg PO qDay
Based on efficacy and tolerability, increase dose in increments of 40 mg/day at intervals of 2 or more days; not to exceed 120 mg/day
Dosage range: 40-120 mg/day
Strong CYP3A4 inhibitors: Not to exceed 80 mg/day levomilnacipran maintenance dose
Hepatic impairment: Hepatic elimination is low, no dosage adjustment required with mild, moderate, or severe hepatic impairment
Mild (CrCl 60-89 mL/min): No dosage adjustment required
Moderate (CrCl 30-59 mL/min): Not to exceed 80 mg/day maintenance dose
Severe (CrCl 15-29 mL/min): Not to exceed 40 mg/day maintenance dose
End-stage renal disease: Not recommended
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Fetzima extended release capsules are used to treat major depressive disorder.
A similar medicine called milnacipran (Savella) is used to treat a chronic pain disorder called fibromyalgia. Fetzima should not be used to treat fibromyalgia.
You should not use Fetzima if you have untreated or uncontrolled narrow-angle glaucoma.
Do not use Fetzima within 7 days before or 14 days after you have taken an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.
People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Tell your doctor right away if you have any sudden changes in mood or behavior, or thoughts about suicide.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Improve Your Symptoms of Depression with Fetzima
It’s believed that a change in the balance of chemicals in your brain, called neurotransmitters, can greatly affect your outlook on life, work, and family. This may cause depression for some individuals because each brain chemical has a job to do and some can affect your moods, behavior, memory, sleep, and so on.
As serotonin and norepinephrine are released from nerve cells in your brain, your mood lightens and you feel pretty good and positive about things. But when these neurotransmitters are reabsorbed, your moods can change. Fetzima inhibits the absorption (reuptake) of serotonin and norepinephrine so there is more available in your brain to prolong your positive mood. Fetzima is not a cure for depression, but it can help you regain the ability to do the things you enjoy.
Conditions Treated by Fetzima
Depression is recognized as a very real medical condition that could also result from traumatic childhood or life events, a chronic illness, substance abuse, work demands, and your gender. Women are more likely to experience depression than men are. It can also run in families so you may be more aware of some of the symptoms you or another family member is displaying, such as sadness, lack of energy or appetite, trouble sleeping or sleeping too much, and suicidal thoughts.
Some individuals may be embarrassed to talk to anyone about their feelings and their mental and physical health can decline unless help is sought. Tell your doctor, tell your family, tell your friends, because a great support system will aid in your recovery.